Retinoic acid receptor ligand. A selective RARα antagonist (concentration required to inhibit 50% of specific retinoic acid binding: RARα, 60 nM; RARß, 2400 nM; RARτ, 3300 nM). Counteracts the effects of retinoic acid on HL-60 cell differentiation, B-lymphocyte polyclonal activation and in a RARα transactivation assay. Ro 41-5253 suppresses retinoic acid-induced connexin 43 protein expression in 10T1/2 cells. Formula: C28H36O5S. MW: 484.7. CAS Number: 144092-31-9. Purity: ≥98% (TLC). Appearance: White solid. Solubility: Soluble in DMSO (50mg/ml) or 100% ethanol (15mg/ml, warm). Long Term Storage: -20°C